Abstract
Background: Contrast-induced acute kidney injury (CI-AKI) is one of the most common causes of hospital-acquired AKI. This study was aimed to analyse the incidence of CI-AKI and associated risk factors in hospitalized patients undergoing CT or Catheter related contrast based procedures. Materials and Methods: This cross-sectional observational study was conducted between September 2016 and August 2018. Hospitalized patients of either sex, aged >18 years scheduled for contrastenhanced computed tomography (CECT), peripheral angiography (PAG), percutaneous transluminal coronary angioplasty (PTCA), or coronary angiography (CAG), with eGFR >30 were evaluated for CIAKI after excluding other causes of AKI. Results: A total of 300 patients were enrolled, of which 266 patients completed the study (CECT/PAG, n=138; PTCA/CAG, n=128). The mean age of the patients was 45.85 15.14 years and the majority of patients were males (n=164, 61.6%). The incidence of CI-AKI was 15.6% (n=41). A total of 28.8% of patients with diabetes and 31.1% patients aged >60 years developed CI-AKI. Overall, the increasing contrast volume significantly (p=0.002) increased the incidence of CI-AKI. The incidence of CI-AKI in patients mild renal dysfunction increased significantly (from 5.5% at Conclusion: Results showed that radio-contrast related procedure carries a significant risk of nephropathy and patients with diabetes, pre-existing renal dysfunction, and advanced age are at higher risk of CI-AKI. Keywords: Chronic kidney disease contrast-induced acute kidney injury contrast media estimated glomerular filtration rate.
Highlights
The first case of contrast-induced acute kidney injury (CIAKI) was reported several decades age[1] and since radio contrast media has been one of the commonest causes of hospital-acquired AKI. 2 Several different definition and classification criteria have been proposed for Contrast-induced acute kidney injury (CI-AKI) leading to marked variation in the reported incidence and outcomes of confidence interval (CI)-AKI
Patients of either sex, aged more than 18 years who were scheduled for contrast-enhanced computed tomography (CECT) or peripheral angiography (PAG) and percutaneous transluminal coronary angioplasty (PTCA) or coronary angiography (CAG), with eGFR more than 30 were eligible for the study
Nephroprotective practice patterns may be partially responsible for the observations in these studies as clinicians are likely to avoid contrast media and employ aggressive preventive measures to patients with risk factors of CI-AKI. 13 The incidence may get affected due to different criteria used for diagnosing CIAKI, and administration of intravascular contrast through varying routes
Summary
The first case of contrast-induced acute kidney injury (CIAKI) was reported several decades age[1] and since radio contrast media has been one of the commonest causes of hospital-acquired AKI. 2 Several different definition and classification criteria have been proposed for CI-AKI leading to marked variation in the reported incidence and outcomes of CI-AKI. The first case of contrast-induced acute kidney injury (CIAKI) was reported several decades age[1] and since radio contrast media has been one of the commonest causes of hospital-acquired AKI. The present article reports results of a study that was aimed to analyse the incidence of CI-AKI, the impact of its various known risk factors, distribution of CI-AKI in catheter-based coronary intervention groups and peripheral computed tomographic angiography (PCTA) based groups, and evaluation of the outcomes of patients who develop a contrast-associated renal injury. This study was aimed to analyse the incidence of CI-AKI and associated risk factors in hospitalized patients undergoing CT or Catheter related contrast based procedures. Conclusion: Results showed that radio-contrast related procedure carries a significant risk of nephropathy and patients with diabetes, pre-existing renal dysfunction, and advanced age are at higher risk of CI-AKI
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