A Historical Overview of the Role of Benzodiazepines including Clonazepam in the Treatment of Adult Restless Legs Syndrome and Periodic Limb Movements in Sleep.

Arthur S Walters,Karen Spruyt,Djibril M Ba,Xiang Gao

doi:10.5334/tohm.824

A Historical Overview of the Role of Benzodiazepines including Clonazepam in the Treatment of Adult Restless Legs Syndrome and Periodic Limb Movements in Sleep.

Arthur S Walters, Karen Spruyt + Show 2 more

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https://doi.org/10.5334/tohm.824

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Journal: Tremor and other hyperkinetic movements (New York, N.Y.)	Publication Date: May 2, 2024
License type: cc-by

#Periodic Limb Movements In Sleep #Limb Movements In Sleep + Show 8 more

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Abstract

Benzodiazepines are frequently used as therapy in Restless Legs Syndrome (RLS) and Periodic Limb Movements in Sleep. The order of benefit is Sleep>RLS>PLMS and arousals > PLMS. For clonazepam dosages of 0.5 mg-2.0 mg/day are most frequently employed. Benzodiazepines exert their therapeutic effect through GABA-ergic mechanisms.

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