A historic overview of the paper: an excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia (1976)

Abstract

The work described in this paper has a long and complex history. Its origin can be traced back to 1964 when, after receiving my M.D. degree, I was offered by Dr. John Vane (whom I had met in Poland in 1963) a postdoctoral fellowship in his laboratory in the Deptartment of Pharmacology, Royal College of Surgeons of England in London. My work there made use of the original blood-bathed organ (BBO) bioassay technique of Vane [1] to study the release of catecholamines by histamine and by peptides, including bradykinin. This was my first introduction into the pharmacology of bradykinin, which turned out to be of great value for its subsequent use in studies of cardiac reflexes. My interest in cardiac reflexes had been stimulated by studies of the adrenergic response associated with acute myocardial infarction in dogs, which were carried out in collaboration with Dr. L. Ceremuzynski during 1967–1970 in the Medical Research Centre of the Polish Academy of Sciences …