Abstract
Cancer Individual tumors consist of a diverse collection of cells with different propensities to grow uncontrollably. This heterogeneity is often associated with the degree of differentiation of the subpopulations of tumor cells. Morales Torres et al. show that the level of a chromatin protein, linker histone H1.0, underlies the variable differentiation and therefore the growth potential of cancer cell populations. Silencing the H1.0-encoding gene allows tumor cells to self-renew, whereas inducing its high expression promotes differentiation and limits tumor maintenance. These findings suggest how modulating epigenetic states might control tumor growth. Science , this issue p. [1514][1] [1]: http://www.sciencemag.org/content/353/6307/1514.full
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