Abstract
Bisphenol A (BPA) is an endocrine disturbing element liberated through the environment and broadly used all over the world. The purpose of this work was to explore the impacts of BPA on liver, spleen and pancreas of adult male albino rats and the probable protecting role of Lycopene. Thirty adult male albino rats were distributed into three groups; group I (control group) , group II administrated BPA orally (50 mg/kg) for 30 days and group III (BPA+ Lycopene treated group) administered Lycopene (LYC) concomitantly with BPA at a dose of 10 mg/kg. At the end of the experiment, rats of all groups were sacrificed. Liver, spleen and pancreas were extracted, fixed and processed for histologic study. The area % of the collagen fibers in liver, spleen and pancreas was measured in the different groups and statistically analyzed. Structural alterations were discovered in liver, spleen and pancreas of BPA-treated rats including dilated congested blood vessels and vacuolar degeneration of the cells. When Lycopene (LYC) was concomitantly administered with BPA, It produced marked improvement at structural and ultrastructural levels. The morphometric results declared that the area % of the collagen fibers in the liver, spleen and pancreases was considerably increased in the BPA-treated group in comparison to the control group. Meanwhile the area % of the collagen fibers of BPA+ Lycopene treated group was more or less comparable to the control group with no significant difference. It was concluded that LYC has noticeable protective effects versus the damaging effects of BPA.
Highlights
Bisphenol A (BPA) is an environmental substance consumed in the manufacture of epoxy resins like food wrapping and can- covering, and plastic products (Fleisch et al, 2010)
The morphometric results declared that the area % of the collagen fibers in the liver, spleen and pancreases was considerably increased in the BPA-treated group in comparison to the control group
This study investigated the effects of BPA on the liver, spleen and pancreas of adult male albino rats and the probable defensive role of LYC
Summary
Bisphenol A (BPA) is an environmental substance consumed in the manufacture of epoxy resins like food wrapping and can- covering, and plastic products (Fleisch et al, 2010). Even small doses of BPA influence growth and reproduction (Welshons et al, 2006). BPA is absorbed from the alimentary canal into blood (Fisher et al, 2011). It is highly conjugated in the liver to create a major metabolite, bisphenol glucuronide, which in turn is eradicated in urine (Pottenger et al, 2000). BPA works as an endocrine disturbing compound [Korkmaz et al, 2010]. It acts as a xenoestrogen regulating the endocrine pathways through a receptor-mediated method (Hatef et al, 2012)
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