A histological study on polyactive� for the prevention of peridural adhesions after spinal surgery: an experimental study in dogs with a 3 months follow-up

Abstract

In the present study the potential of Polyactive® bilayer sheets in the prevention of scar tissue formation after spinal surgery was investigated. Eight adult beagle dogs underwent 3 laminectomies at three levels (L2, L4 and L6). According to a randomized implantation schedule a Polyactive® sheet or autogenous fat graft was placed in the defect. The third site served as a control without implant. After 4 or 12 weeks (4 dogs per period) the dogs were sacrificed and histological sections were prepared. The Polyactive® treated defects showed partial closure by newly formed bone. The Polyactive® was encapsuled by a thin fibrous tissue layer. Ventral to the defect, dense fibrous tissue was present which was separated from the dura by the Polyactive® sheet in all cases. In some cases fibrous tissue was present between the implant capsule and the dura. In the fat graft group there were no signs of closure of the defect but most sites showed fibrous tissue at the edges of the graft, which was in 4 sites continous with the dura mater. Fibrosis and degeneration of the fat grafts were seen. All control defects showed partial closure by newly formed bone, and ventral to the defect extensive fibrous tissue, which was in 50% continous with the dura mater. Other sections showed loose connective tissue in contact with the dura mater. It is concluded that Polyactive® has a potential as a mechanical barrier in the prevention of adhesions between the dorsal spinal muscles and the dura mater.