Abstract
In a combined histological, biochemical, and histochemical study of the macroscopically normal white matter in multiple sclerosis (MS), 72% of samples were histologically abnormal. The significance of this fact in the interpretation of previous biochemical studies and in the design of future studies is discussed. Acid phosphatase was studied histochemically in the microscopically normal white matter in MS: there was an increase in acid phosphatase-containing cells as compared with normal and neurological control material. The significance of this finding is discussed and it is suggested that irrespective of the primary or secondary nature of this phenomenon, it may render the white matter susceptible to the pathogen in this disease.
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