Abstract
The mid-portion of the gracilis muscle from three apparently normal marmosets and six marmosets suffering from a sporadic wasting disease in a large colony where the condition caused considerable losses was removed and examined histologically and histochemically. Muscle fibres from apparently normal marmosets were a typical polyhedral shape and were of relatively uniform size. Muscle fibres from wasted animals exhibited a “rounding up” and a severe atrophy of many fibres, together with a marked increase in connective tissue, was observed. Hyaline degeneration was seen and the presence of basophilic fibres with central vesicular nuclei was considered indicative of regeneration. When examined for myosin ATPase, NADH-tetrazolium reductase and phosphorylase activity, the majority of atrophied fibres gave a Type II enzyme profile. The possible aetiology of the myopathy is discussed.
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