Abstract
Growth at the sutures surrounding the premaxilla and in the periosteum covering its surfaces was studied histologically and enzyme-histochemically in normal human material between the 11th intrauterine week and one year after birth. In foetuses (11 to 17 weeks i-u.l.). there was evidence of differing rates of bone deposition at the growth sites. Both foetuses and neonates (26 weeks i-u.l. to 1 year of age) exhibited continuing osteogenesis which resulted in a prominent increase in the breadth of the premaxilla. Particularly during later stages, the premaxilla showed evidence of growth directed mainly downwards. In some neonatal specimens, small conglomerates of cartilage-like cells were found at the bony margins of the inter- and vomero-premaxillary sutures as well as in the inferior part of the alveolar process.
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