Abstract
Mammary gland tissue from pregnant mice undergoes specific changes in structure and function when incubated in vitro on synthetic medium containing insulin, hydrocortisone, and prolactin. This combination of hormones increases the rate of synthesis of one group of phosphoproteins, casein, 300–550%, while the synthesis of other phosphoproteins is only slightly stimulated. This selective biosynthetic response is paralleled by specific histological changes in the alveolar epithelium of the gland. The combination of specific changes in cell and tissue structure and selective stimulation of one group of milk proteins constitutes an example of cellular differentiation under hormonal control.
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