Abstract
Joro spider toxin (JSTX), a specific blocker of glutamate receptors, was conjugated with biotin. Using the avidin-biotin complex method, specific binding sites of biotinylated JSTX were demonstrated in the cerebellum and hippocampus of the rat. In the cerebellum, strong binding of biotinyl JSTX was observed on perikarya and dendrites of the Purkinje cells with much less binding in the granular cell layer. In the hippocampus, a dense staining was observed in the pyramidal cell layer, with more heavy binding in CA3 than in other sectors of Ammon's horn. The area of distribution of biotinyl JSTX binding sites corresponded well with that of receptors preferentially activated by quisqualate.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
