Abstract
Alkaline and acid DNase and RNase activities were investigated histochemically in human brain. Intense activity of alkaline nucleases was found mainly in the choroid plexus and ependymal epithelium as well as in the leptomeninges. Acid nuclease activity was strongest in all nerve cells. The glial cells demonstrated very weak activity of both acid and alkaline nucleases. Comparison of these results with the incidence of human brain malignant tumours has indicated that low nuclease activity in normal brain cells coincides with the high incidence of malignant tumours deriving from these cells and vice versa. These observations and the results of similar investigations in the rat CNS and in the digestive tube of the rat and man suggest that low nuclease activity in normal cells could be considered to be a factor which may predispose to malignant trans-formation.
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