Abstract
An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better. This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost. It was developed from a single-head clinical SPECT scanner, with a seven-pinhole collimator and a four-degree-of- freedom motion control stage. Several key techniques were developed, including high-resolution image reconstruction algorithm, high accuracy geometrical calibration method, and optimized system matrix derivation scheme. The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function. Experiments of point source and ultra micro hot rod phantom were conducted. With a spatial resolution of 0.5-0.6 mm, this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.
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