Abstract
Developing highly specific and ultrasensitive techniques for monitoring hypochlorous acid (HOCl) in the environment and living systems is very important to guarantee its safe use and disclose its diverse biological functions. We herein presented a simple water-soluble lysosome-targeted fluorescent probe TCRH for the detection of HOCl. Probe TCRH could sensitively monitor HOCl at the nanomolar levels with the detection limit of 0.12 nM. Additionally, probe TCRH with the response unit of thiocarbamate could selectively detect HOCl over other various analytes. Furthermore, probe TCRH showed an ultrafast response for HOCl (<3 s), implying that it could offer a real-time analytical assay of HOCl. Finally, probe TCRH was used for monitoring the basal lysosomal HOCl levels without exogenous stimuli and tracking the fluctuations of endogenous/exogenous HOCl levels in the lysosomes of live RAW 264.7 macrophage cells.
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