Abstract
A fluorescence probe has been designed and synthesized, and applied with a combined theoretical and experimental study. Research suggests that the probe can be used to sense Zn2+ and Hg2+ through selective turn-on fluorescence responses in the aqueous HEPES buffer (0.05M, pH=7.4). The limit of detection (LOD) were determined as 1.46×10−7M (Zn2+) and 2.50×10−7M (Hg2+). Moreover, based on DFT, the geometry optimizations of probe 1, [1-Hg2+] complex and [1-Zn2+] complex were carried out using the Gaussian 09 program, in which the B3LYP function was used. The electronic properties of free probe 1 and the metal complexes were studied based on the Natural Bond Orbital (NBO) analyses. The probe 1 has also been successfully applied to detection of Zn2+ and Hg2+ in living cells.
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