Abstract
Chemosensor C1, namely, 3-acetoacetyl-7-hydroxycoumarin, was synthesized and exhibited highly selective and sensitive fluorescence sensing ability for Cu2+ over other metal ions under physiological conditions. The fluorescence quenching response of C1 for Cu2+ indicated that C1 can be used as an on-off fluorescent chemosensor to selectively detect Cu2+. The binding process was confirmed by UV–vis absorption, fluorescence measurement, mass spectroscopy, IR spectra and DFT calculation. To test the practical use of the probe, the determination of Cu2+ in real water samples was evaluated. The application of the fluorescent probe in monitoring intracellular Cu2+ in HeLa cells has also been demonstrated.
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