Abstract
Abstract Functionalized graphene-based nanocomposites have opened new windows to address some challenges for increasing the sensitivity, accuracy and functionality of biosensors. Polyaniline (PANI) is one of the most potentially promising and technologically important conducting polymers, which brings together the electrical features of metals with intriguing properties of plastics including facile processing and controllable chemical and physical properties. PANI/graphene nanocomposites have attracted intense interest in various fields due to unique physicochemical properties including high conductivity, facile preparation and intriguing redox behavior. In this article, a functionalized graphene-grafted nanostructured PANI nanocomposite was applied for determining the ascorbic acid (AA) level. A significant current response was observed after treating the electrode surface with methacrylated graphene oxide (MeGO)/PANI nanocomposite. The amperometric responses showed a robust linear range of 8–5,000 µM and detection limit of 2 µM (N = 5). Excellent sensor selectivity was demonstrated in the presence of electroactive components interfering species, commonly found in real serum samples. This sensor is a promising candidate for rapid and selective determination of AA.
Highlights
Biosensors have attracted much attention due to their unique properties such as simple procedure, easy production, fast response and cost efficiency [1,2,3]
Electrodepositing PANI on the methacrylated graphene oxide (MeGO)-grafted FTO was initiated with 20 successive cyclic voltammograms (CVs) in a solution consisting of 0.03 M aniline monomer
The black regions and transparent edges were ascribed to PANI and MeGO nanosheets in MeGO/PANI nanocomposite, respectively
Summary
Biosensors have attracted much attention due to their unique properties such as simple procedure, easy production, fast response and cost efficiency [1,2,3]. Electrochemical methods have established rapid and low-cost performance as well as fast response with high selectivity, stability and sensitivity in determining some biomolecules and analytes [54]. Nanostructured composites such as palladium (Pd) nanowire-modified graphene [55], multiwall CNTs dispersed in polyhistidine [56], Fe3O4@gold (Au)-loaded graphene [57] and ZnO nanowire on hierarchical graphene [58] were reported for developing the sensitivity and selectivity of AA. A simpler nanocomposite based on MeGO-grafted PANI is applied as electrochemical biosensor that has several benefits including cost efficiency, high sensitivity and good selectivity over AA determination.
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