Abstract
Diabetes is one of the metabolic diseases marked by hyperglycemia. Beta-hydroxybutyrate (β-HB) is a biomarker that has closely associated with the occurrence and development of diabetes. So far, there is no fluorescent sensor reported for detecting β-HB in aqueous solution or living cells. Here, new Schiff base fluorescent probes (TA, TB, TC) were designed and synthesized to detect β-HB. The probe TC can detect β-HB sensitively and selectively in DMSO/H2O (v:v = 90:10, 5.0 × 10−5 M) solution. Meanwhile, the possible binding mechanism between probe TC and β-HB was proposed and verified by the NMR experiment and mass spectra experiment. Furthermore, based on the low cell cytotoxicity of TC, it has been applied in imaging exogenous β-HB in HUEVC cells successfully. Probe TC could be used for the early detection of diabetic ketoacidosis (DKA).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
