A Highly Selective Turn-On Fluorescent Probe for the Detection of Zinc.

Ling-Yi Shen,Xiao-Li Chen,Ya-Li Huang,Xian-Jiong Yang,Carl Redshaw,Qi-Long Zhang,Hong Xu,Xing Zhang

doi:10.3390/molecules26133825

Ling-Yi Shen, Xiao-Li Chen + Show 6 more

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https://doi.org/10.3390/molecules26133825

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Abstract

A novel turn-on fluorescence probe L has been designed that exhibits high selectivity and sensitivity with a detection limit of 9.53 × 10−8 mol/L for the quantification of Zn2+. 1H-NMR spectroscopy and single crystal X-ray diffraction analysis revealed the unsymmetrical nature of the structure of the Schiff base probe L. An emission titration experiment in the presence of different molar fractions of Zn2+ was used to perform a Job’s plot analysis. The results showed that the stoichiometric ratio of the complex formed by L and Zn2+ was 1:1. Moreover, the molecular structure of the mononuclear Cu complex reveals one ligand L coordinates with one Cu atom in the asymmetric unit. On adding CuCl2 to the ZnCl2/L system, a Cu-Zn complex was formed and a strong quenching behavior was observed, which inferred that the Cu2+ displaced Zn2+ to coordinate with the imine nitrogen atoms and hydroxyl oxygen atoms of probe L.

Highlights

Zinc is the second most abundant transition metal ion in the human body and is essential for various biochemical processes, such as neurotransmission, enzyme regulation, gene expression, and apoptosis [1,2,3,4]
5%, and the fluorescence response of L to metal ions was recorded in ethanol solution excited at 354 nm as shown in spectral of L to metal ions was recorded solution at evaluated
It was found that probe L has great fluorescence selectivity for Zn2+ over many other important metal ions

Summary

Introduction

Zinc is the second most abundant transition metal ion in the human body and is essential for various biochemical processes, such as neurotransmission, enzyme regulation, gene expression, and apoptosis [1,2,3,4]. It is of great significance to be able to accurately detect zinc ion concentration [15,16,17,18]. Metal ion fluorescent chemical sensors have attracted much attention because of the convenient use, high sensitivity, and ability to directly measure concentration through fluorescent signals [23,24,25,26,27]

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