Abstract
The present study is designed to further elucidate the molecular genetic basis of migraine with and without aura. Migraine is a common disease of as yet unknown etiology. Interest in ion channels in migraine has been spurred by molecular genetic findings in familial hemiplegic migraine, since familial hemiplegic migraine type 1 is caused by mutations in the calcium channel gene CACNA1A. Given this role of ion channels in migraine, we assessed the potassium channel KCNN3 as a candidate gene for common migraine. We analyzed the highly polymorphic repeat region coding for a poly-glutamine stretch, which constitutes part of the cytoplasmic tail of the channel protein. We found an excess of the allele coding for 15 poly-glutamines in migraine patients. The potassium channel KCNN3 may thus be of pathophysiological importance in migraine with and without aura.
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