Abstract
The potent anthelmintic cyclooctadepsipeptide PF1022A was synthesized by a series of fragment condensations starting from the known ( S)-2-chloropropanoic acid and ( S)-2-chloro-3-phenylpropanoic acid in eleven steps with a total yield of 13%. Noteworthy is the excellent yield of the BOP-Cl mediated lactamization reaction of the linear precursor 17 leading to the 24-membered macrocycle.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
