Abstract
A new indolylphosphine WK‐phos has been synthesized for Pd‐catalyzed Suzuki–Miyaura coupling of (hetero)aryl chlorides with (alkyl)arylboronic acids. Comprising this newly developed ligand with palladium(II) acetate, the resulting catalyst system was found to be highly effective in facilitating the reaction even when the catalyst loading reaches parts per million levels (e.g. 10 ppm). These examples represent one of the lowest catalyst loadings reported to date of employing monophosphine (e.g. Ar‐PCy2) for Suzuki–Miyaura reactions. The ligand geometry has also been well‐characterized by single‐crystal X‐ray crystallography.
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