Abstract
An LC/MS/MS method was developed to quantify carboplatin and eribulin mesylate (E7389) in human plasma and urine. For carboplatin, sample clean-up by protein precipitation and supernatant injection into a Waters Spherisorb ® S5 SCX column was used. Liquid-phase extraction and reverse-phase chromatography on a Polaris ® C18 column were used for eribulin. Quantitation involved LC/MS/MS with positive electrospray ionization. Accuracy, precision, linearity, range, specificity, recovery and stability were also evaluated. Both compounds were stable in human plasma (≥80 days at −80 °C), at room temperature (≥4 h), following three freeze–thaw cycles and in 50/50 methanol/H 2O (<4 °C for ≥252 days).
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