Abstract
Abstract Ranitidine hydrochloride is a highly potent H2 receptor antagonist of value in the treatment of peptic ulceration. A method is described for the determination of ranitidine in biological fluids. The drug is extracted from plasma prior to determination by reverse phase high performance liquid chromatography. The method is sensitive enough to determine 10ng ranitidine per ml in plasma. The h.p.l.c. method has been automated so that analysis can be carried out without attention over a 24 hour period. The automated h.p.l.c. method has been used for studying the pharmacokinetics of oral and intravenous doses of ranitidine hydrochloride administered to man.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
