Abstract
Infections caused by multi-drug resistant (MDR) Gram-negative (GN) organisms in critically ill patients are a therapeutic challenge. Few therapeutical options are available.
Highlights
Infections caused by multi-drug resistant (MDR) Gramnegative (GN) organisms in critically ill patients are a therapeutic challenge
A high aminoglycoside regimen associated with renal replacement therapy for the treatment of multi-drug resistant pathogens
The administration of high-dose aminoglycoside (HDA) therapy coupled with high-flow continuous veno-venous hemodiafiltration (CVVHDF) could allow required high drug peaks to be achieved with reduced toxicity
Summary
Infections caused by multi-drug resistant (MDR) Gramnegative (GN) organisms in critically ill patients are a therapeutic challenge. A high aminoglycoside regimen associated with renal replacement therapy for the treatment of multi-drug resistant pathogens A Brasseur1*, M Hites2, S Roisin3, F Cotton4, J-L Vincent1, D De Backer1, F Jacobs2, FS Taccone1
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