Abstract
Sequential L,D polypeptides have been the object of investigations by many authors (1–4), since it was realized that they are strictly related to a natural occurring peptide, gramicidin A, which forms monovalent cation selective transmembrane channels in biological membranes and lipid bilayers (5,6). Here we present the results obtained by x-ray analysis of a linear hexapeptide, Boc-(D-aIle-L-Ile) 3-OMe, which, in the solid state, gives rise to a chain reversal stabilized by multiple intramolecular hydrogen bonds. It is the first description of a β-turn (C 10) and an α-turn (C 13) fused together and included in a larger 17-membered ring (C 17) occurring in a linear peptide.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
