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Abstract
A H4SiW12O40-catalyzed three-component tandem reaction of 2-acylbenzoic acids, primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed. By employing H4SiW12O40 as the catalyst and dimethyl carbonate (DMC) as the solvent, a diverse range of 2-acylbenzoic acid derivatives and primary amines worked well to give the C3-phosphinoyl-functionalized 3,3-disubstituted isoindolinones with the yield range of 61%-87%. Advantages of this transformation include green catalyst and solvent, available starting materials, broad substrate scope, high efficiency and operational simplicity with water as the sole by-product. The strategy achieved an efficient and green molecular fragment assembly to access isoindolinones, which would provide opportunities for the synthesis of potential biologically active molecules in a green manner.
Published Version
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