Abstract
Biomaterials A large proportion of the population suffers from gastrointestinal disease involving either chronic conditions like Crohn's disease or acute conditions like peptic ulcers. It would be ideal to be able to track changes in local conditions, like pH, with functional changes such as motility. Huang et al. developed an ingestible sensor based on gold triangular nanoplates coated with polyaniline (PANI), as both materials are stable across a wide pH range. The gold shows strong near-infrared absorption around 1200 nanometers, whereas PANI absorbs around 790 nanometers, but only PANI shows absorption changes with changing pH. Photoacoustic imaging is used to detect changes in absorption, and thus pH, while also allowing for real-time tracking of gastric contractions, gastric emptying, and transit time. ACS Nano 10.1021/acsnano.9b04541 (2019).
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