Abstract
Abstract Thrombotic microangiopathies are rare life-threatening diseases that require prompt diagnosis and treatment to increase patient survival. The prototypical thrombotic microangiopathies are classic hemolytic-uremic syndrome, caused by enterohemorrhagic Escherichia coli, and thrombotic thrombocytopenic purpura. Included in the differential diagnoses and showing overlapping clinical features is antiphospholipid syndrome (APS) and the more severe form, catastrophic APS. Here, we discuss the general approach to thrombotic microangiopathies through a case of APS that later developed into its catastrophic variant.
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