A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on “A haplotype of human angiotensinogen gene containing −217A increases blood pressure in transgenic mice compared with −217G,” by Jain et al.

Abstract

the prevalence of hypertension across the globe continues to rise despite advances in treatment and an ever-growing battery of antihypertensive drugs. Untreated hypertension remains an important risk factor for cardiovascular diseases, including stroke. The renin-angiotensin system (RAS) has long