A Gr/αFe2O3/Carbon Paste Electrode Developed as an Electrochemical Sensor for Determination of Rizatriptan Benzoate: An Antimigraine Drug

Abstract

AbstractIn this research, a new electrochemical sensor was proposed for determining rizatriptan benzoate (RZB) with high sensitivity. To this end, a nanocomposite consisting of graphene (Gr) and hematite iron oxide (αFe2O3) was used to modify a carbon paste electrode (CPE). Field emission scanning electron microscopy (FESEM) was employed to study the morphology of the fabricated electrode; cyclic voltammetry (CV), chronoamperometry (CA), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) were utilized to evaluate the modified electrode's capabilities. The findings demonstrated the high sensitivity of the designed electrode in the determination of RZB. In addition, to optimize the response of the electrochemical sensor, changes in the voltammetric behavior of RZB under different scan rates and pH conditions were explored. The results showed that under optimal conditions, RZB concentrations between 2 and 50 μM induced an oxidation anodic peak current that could detect the substance with a low limit of merely 0.42 μM. The findings of the present study demonstrated the fabricated electrode high sensitivity, low detection limit, wide linear dynamic range, remarkable reproducibility, rapid response, and high current peak response in detecting various concentrations of RZB. Furthermore, a kinetically facile system with minimal charge transfer resistance and adequate RZB diffusion was present on the electrode surface. Finally, the proposed electrode was successfully utilized in the detection of RZB in various samples.