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Abstract
ABSTRACT A series of warfarin analogs, β-aminomethylhydroxylcoumarins, was obtained in good yields from the Mannich reaction of 4-hydroxycoumarin, aromatic aldehydes and secondary amines in water under microwave irradiation at 100 °C. The salient features of the synthesis are: catalyst-free protocol, green solvent (water), complete avoidance of organic solvents in the synthesis, facile workup and high yields.
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