A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst

Abstract

The first zinc-catalyzed simple and convenient protocol for the synthesis of N-substituted pyrroles through a modified Clauson-Kaas reaction without co-catalyst, ligand, base and solvent has been described. N-substituted pyrroles were prepared from various aniline derivatives and 2,5-dimethoxytetrahydrofuran under green condition by utilizing low cost, eco-friendly, non-toxic and easily accessible Zn(OTf)2 as catalyst. A wide variety of N-substituted pyrroles were afforded in moderate to excellent yields from easily available starting materials at 70 °C.