A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5-d]pyrimidinones using a Biginelli-like reaction

Abstract

In this article, we have demonstrated a green and facile one-pot approach for the regio- and chemoselective synthesis of 5-aryloyl-1,3-dimethyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives in water at 50 °C. This transformation presumably proceeds via a three-component tandem annulation of arylglyoxalmonohydrates with 1,3-dimethylbarbituric acid and thiourea in the presence of catalytic amounts of DABCO or l-proline, involving a Biginelli-like reaction.