Abstract
DES (deep eutectic solvents) [CholineCl][ZnCl2]3, which easily prepared from choline chloride and zinc chloride (ZnCl2), is useful for the acylation of secondary alcohols with acid anhydrides. Acylation of alcohols with acid anhydrides as acylating reagent using [CholineCl][ZnCl2]3 as a catalyst was investigated under the ultrasonic method. Six secondary alcohols were investigated and afforded high yields (88-96%). The desired products were characterized by NMR and GCMS spectra. Different from traditional Lewis acidic catalysts, [CholineCl][ZnCl2]3 was found to be an efficient catalyst for acylation of alcohols under mild conditions. By using the ultrasonic method, the processes gave high yield; the catalyst is cheap, easy to handle, recyclable for several times without significant loss of the catalytic activity.
Highlights
DES [CholineCl][ZnCl2]3, which prepared from choline chloride and zinc chloride (ZnCl2), is useful for the acylation of secondary alcohols with acid anhydrides
[CholineCl][ZnCl2]3 as a catalyst was investigated under the ultrasonic method
The desired products were characterized by NMR and GCMS spectra
Summary
DES (deep eutectic solvents) [CholineCl][ZnCl2]3, được tạo thành từ choline chloride và zinc chloride (ZnCl2), với những ưu điểm vượt bậc như dễ dàng điều chế bằng phương pháp đun khuấy từ, xúc tác hiệu quả cho phản ứng acyl hóa các alcohol bậc 2 và anhydride acid với quy trình thực hiện phản ứng đơn giản dưới sự kích hoạt bằng phương pháp siêu âm cho hiệu suất cao. Quy trình điều chế DES được thực hiện dễ dàng, tạo ra xúc tác có hoạt tính cao và bền trong môi trường phản ứng, hơn SCIENCE & TECHNOLOGY DEVELOPMENT JOURNAL: NATURAL SCIENCE, VOL 1, ISSUE 6, 2017 thế nữa, loại xúc tác này dễ dàng được thu hồi và tái sử dụng nhiều lần mà hoạt tính giảm không đáng kể. Cột: DB-5MS; phổ NMR được đo trong dung môi CDCl3 trên máy Bruker 500MHz với chất chuẩn TMS
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