Abstract
An analytical method for the determination of hydroxyethoxyphenyl butanone, which is used as an alternative preservative in cosmetic products, has been developed and validated for the first time. The method is based on a simple ultrasound-assisted lixiviation of the analyte from the cosmetic matrix followed by liquid chromatography with UV spectrophotometric detection. Under optimized conditions, the method limit of detection and limit of quantification values were 30 and 90 µg·g−1, respectively. The method was validated with good recovery values (86–103%) and precision values (RSD 0.2–4.7%). Finally, the proposed analytical method was successfully applied to 7 commercially available cosmetic samples including both lipophilic and hydrophilic matrices, such as moisturizing cream, sunscreen, shampoo, liquid hand soap, and make-up. Additionally, a laboratory-made cosmetic cream containing the target analyte was prepared and analyzed. The good analytical figures of merit of the proposed method, in addition to its environmentally-friendly characteristics, demonstrate its usefulness to perform the quality control of cosmetic products to ensure the safety of consumers.
Highlights
1223/2009) [1], ‘cosmetic product’ means ‘any substance or mixture intended to be placed in contact with the external parts of the human body or with the teeth and the mucous membranes of the oral cavity with a view exclusively or mainly to cleaning them, perfuming them, changing their appearance, protecting them, keeping them in good condition or correcting body odors’
Cosmetic formulations generally include a variety of different types of ingredients, such as excipients, active principles and several additives
Some cosmetic ingredients can play more than one role in a cosmetic formulation, leading to cosmetic products that are free of preservatives or self-preservatives [3,4,5]
Summary
According to the current European Regulation of Cosmetic Products (EU Regulation. 1223/2009) [1], ‘cosmetic product’ means ‘any substance or mixture intended to be placed in contact with the external parts of the human body (epidermis, hair system, nails, lips and external genital organs) or with the teeth and the mucous membranes of the oral cavity with a view exclusively or mainly to cleaning them, perfuming them, changing their appearance, protecting them, keeping them in good condition or correcting body odors’. The sample preparation of the proposed method based on a Among the different ultrasound‐assisted lixiviation of thein analyte followed by its determination by LC‐UV/Vis. Thefar the most frequently types of green cosmetic preservatives studied the analytical literature, parabens are by proposed LC‐UV/Vis method provides limits of detection and quantification far below the limits analyzed, whereas the number of published papers dealing with the analysis of other preservatives is contemplated in the abovementioned SCCS opinion. The proposed LC-UV/Vis method provides limits of detection and quantification far below the limits contemplated in the abovementioned SCCS opinion These characteristics make the proposed method useful to perform the pre- and in-market analytical control of cosmetic products, in order to assure their safety
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
