A Green and Ecofriendly Catalytic System for One-Pot Three-Component Synthesis of 5-Substituted 1H-Tetrazoles Under Microwave Irradiation

Abstract

In this research work, the high-yielding and simple synthesis of 5-substituted 1H-tetrazoles derivatives through the one-pot three-component reaction of aldehydes, hydroxylamine hydrochloride and sodium azide catalyzed by MNPs-Picolylamine-Cu(OAc)2 nanocomposite in water under microwave irradiation has been reported. The MNPs-Picolylamine-Cu(OAc)2 nanocomposite is successfully fabricated through the immobilization of copper (II) acetate stabilized on magnetic Fe3O4 nanoparticles modified with Picolylamine [MNPs-Picolylamine-Cu(OAc)2] and then is well analyzed by various techniques such as FT-IR, XRD, TGA, SEM, TEM, EDS, VSM and ICP-OES. At the end of the reaction, the MNPs-Picolylamine-Cu(OAc)2 catalyst can be easily recycled and reused and the products obtained had high efficiency and purity.