A green and eco-efficient protocol for the synthesis of benzo-[7]-annulene-1,3-dicarbonitriles by using simple mortar pestle grinding

Abstract

The synthesis of novel benzo-[7]-annulene-1,3-dicarbonitrile analogues has been accomplished using an environmentally friendly and green protocol. This mortar and pestle grinding method that is both ethically responsible and commercially practical. By producing the necessary benzo-[7]-annulene-1,3-dicarbonitrile analogues with good results (89%–97%) in a short reaction time (≤30 min), this approach successfully indicates that even aldehydes with severe steric hindrance play an active part in the process. The faster work-up processes, the reduction of operating difficulties, and the increased yields are notable among its advantages over earlier systems. This strategy uses a mortar and pestle grinding method, which is well known for following guidelines that are both economically sensible and environmentally friendly. It is important to note that this novel approach offers a considerable advancement over earlier approaches that were characterized by drawn-out work-up procedures, operational complexity, and low yields.