Abstract
There is no doubt that cancer is now one of the most formidable diseases in the world; despite all the efforts and research, common treatment routes, including chemotherapy, photodynamic therapy, and photothermal therapy, suffer from different limitations in terms of their efficiency and performance. For this reason, different strategies are being explored to improve the efficiency of the traditional drugs reported to date. In this study, we have redirected the function of one of these drugs (5-fluorouracil, 5-FU) by combining it with a graphene–gold nanocomposite in different molar ratios that has been exceedingly used for biological research development. The high activity of the graphene–gold material enables it to produce reactive oxygen and ions, which display good anticancer and antioxidant activity through the scavenging of the DPPH, SOD and GPx radicals; in addition, different characterizations have been used to confirm the structure and morphology of the obtained samples. Highly potent cytotoxicity against the MCF-7 cells was achieved with the drug combination containing the nanocomposite. All the results, including those obtained via cytometry, indicate that the combination of 5% graphene–gold nanocomposites with 5-FU exhibits a higher antitumor impact and more drug stability than pure 5-FU.
Highlights
Breast cancer is a formidable disease that is faced by a large population of women.[1]
Many parameters may increase the efficacy of 5- uorouracil (5FU) against the development of the disease as breast cancer includes genetic, environmental, natural and physiological factors;[10,11,12,13,14] chemotherapy, hormone therapy and targeted therapy summarize the main approaches that are approved for curing breast cancer, but each method has its own side effects and drawbacks
The mechanism for obtaining the proposed structure of the reduced graphene oxide (rGO)–Au nanocomposites has been reported in the literature.[44,45,46]
Summary
Breast cancer is a formidable disease that is faced by a large population of women.[1].
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