Abstract
Electron Microscopy Electron microscopy (EM) is an attractive method for determining structures of protein complexes that are difficult to crystallize. Exciting recent developments in electron detectors allow EM structure determination to near atomic resolution. A key impediment to further improvement is that single specimens move during irradiation. Russo and Passmore designed a gold support that moves much less during irradiation than the current support and as a result prevents movement of the protein sample. Using the support they determined the structure of apo-ferritin which, as a spherical shell of α-helices, is particularly challenging to solve by EM. Science , this issue p. [1377][1] [1]: /lookup/volpage/346/1377?iss=6215
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