Abstract
Germ-free weanling rats belonging to two separate strains with differing levels of caries activity were produced by time-mating, hysterectomy and fostering onto germ-free lactating females of a third strain. They were mono-infected with a cariogenic oral microorganism, and then fed for 8 weeks on a sterilized 46% sucrose diet under either (a) gnotobiotic or (b) conventional conditions. The clear interstrain difference in dental caries level was maintained under both conditions, showing that caries activity was hereditable and not dependent on the type of oral microflora harboured by the two strains.
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