Abstract
Regulators of vertebrate Ath5 expression were identified by high-throughput screening; extending the current gene regulatory model network controlling retinal neurogenesis.
Highlights
Investigating the architecture of gene regulatory networks (GRNs) is essential to decipher the logic of developmental programs during embryogenesis
The trans-regulation screen identifies candidate regulators of Ath5 To gain insight into the molecular mechanisms controlling the dynamic expression of Ath5, we explored the regulatory logic of a medakafish 3-kb promoter fragment that fully reca
These findings indicate that transregulatory input from both cell-intrinsic factors and extracellular signals converges on the Ath5 promoter to precisely control the timing of retinal ganglion cell (RGC) differentiation
Summary
Investigating the architecture of gene regulatory networks (GRNs) is essential to decipher the logic of developmental programs during embryogenesis. Gene regulatory networks (GRNs) determine the animal body plan and cooperate to specify the different cell types of the organism. They have evolved to integrate and precisely control developmental programs. The control of retinal progenitor cell (RPC) fate-choice and differentiation depends on the synchronization of intrinsic genetic programs and extrinsic sig-. Genome Biology 2009, Volume 10, Issue 9, Article R92 Souren et al R92.2 nals. A hierarchical GRN controls the sequential generation of the different retinal cell types during embryogenesis [2]. S-phase takes places at the basal side of the epithelium, while M-phase nuclei are located at the apical side [7,8,9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
