Abstract
Regulators of vertebrate Ath5 expression were identified by high-throughput screening; extending the current gene regulatory model network controlling retinal neurogenesis.
Highlights
Investigating the architecture of gene regulatory networks (GRNs) is essential to decipher the logic of developmental programs during embryogenesis
The trans-regulation screen identifies candidate regulators of Ath5 To gain insight into the molecular mechanisms controlling the dynamic expression of Ath5, we explored the regulatory logic of a medakafish 3-kb promoter fragment that fully reca
These findings indicate that transregulatory input from both cell-intrinsic factors and extracellular signals converges on the Ath5 promoter to precisely control the timing of retinal ganglion cell (RGC) differentiation
Summary
Investigating the architecture of gene regulatory networks (GRNs) is essential to decipher the logic of developmental programs during embryogenesis. Gene regulatory networks (GRNs) determine the animal body plan and cooperate to specify the different cell types of the organism. They have evolved to integrate and precisely control developmental programs. The control of retinal progenitor cell (RPC) fate-choice and differentiation depends on the synchronization of intrinsic genetic programs and extrinsic sig-. Genome Biology 2009, Volume 10, Issue 9, Article R92 Souren et al R92.2 nals. A hierarchical GRN controls the sequential generation of the different retinal cell types during embryogenesis [2]. S-phase takes places at the basal side of the epithelium, while M-phase nuclei are located at the apical side [7,8,9]
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