Abstract
Desmoid tumours are rare mesenchymal tumours, often locally invasive and characteristically associated with a high local recurrence rate after resection. A potential aetiological role for female hormones is indicated. Pregnancy-associated desmoid tumours are almost exclusively located in the abdominal wall. An essential issue is how to counsel women who have had a pregnancy-associated desmoid tumour and subsequently wish to bear a child. A considerably rare case of a patient with a resection of a giant pregnancy-associated, 33 cm in diameter, intra-abdominal desmoid tumour is presented. After a subsequent pregnancy, the patient delivered healthy twins 26 months later. Fifty-four months after treatment, there are no signs of recurrent or second desmoid tumour. Although rarely located in the abdomen, pregnancy-associated desmoid tumours should be included in the differential diagnosis of intra-abdominal tumours detected during or shortly after pregnancy. Based on this case and a few others reported in the literature, subsequent pregnancy does not necessarily seem to be a risk factor for recurrent or new disease.
Highlights
Desmoid tumour, called aggressive or desmoid-type fibromatosis, is a rare monoclonal, fibroblastic proliferation
Only a few cases have been reported, desmoid tumour should be included in the differential diagnosis of intra-abdominal tumours detected during or shortly after pregnancy
Conclusions pregnancy-associated desmoid tumours are almost exclusively located in the abdominal wall, desmoid tumour should be included in the differential diagnosis of intra-abdominal tumours detected during or shortly after pregnancy
Summary
Called aggressive or desmoid-type fibromatosis, is a rare monoclonal, fibroblastic proliferation. Histologically benign and unable to give rise to metastases, desmoids are often locally invasive and characteristically associated with a high local recurrence rate after resection. While this fibroblastic disorder may be observed in nearly every part of the body, desmoids occur most commonly in extremities. Histological examination demonstrated a mesenteric desmoid tumour (Figure 5) which had infiltrated the transverse colon as well as the surface of the resected part of the pancreas. The patient did not receive any adjuvant treatment She became spontaneously pregnant, despite the recommendation that she postpone pregnancy to allow for a 2-year disease-free follow-up period. Fifty-four months after resection of the desmoid, she is in excellent condition without any sign of tumour recurrence on abdominal sonography and MRI, or of development of a second desmoid tumour
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