Abstract
A NOVEL APPROACH is expanding the versatility of flow cytometry, a particle counting and sorting technique that has been a workhorse of biology labs for decades. In flow cytometry, researchers use fluorescently labeled antibodies to distinguish among different types of cells. But the need for distinct fluorescent labels and overlap between their fluorescence spectra limit the number of parameters that can be measured in a single analysis. “There are just so many places along the spectrum that we can create dyes that are sufficiently distinct,” says Garry P. Nolan, a Stanford University biologist who uses flow cytometry to study single cells. “We’re effectively stuck at somewhere between 10 and 15 parameters.” Now a relatively new method greatly expands the number of parameters that can be measured simultaneously. Developed over the past 10 years by Scott D. Tanner, a chemist at the University of Toronto, the technique, mass cytometry, has the potential to measure 50 or ...
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