Abstract
MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF), play a pivotal role in the activties of tumor cells. A germline missense variant in exon 2 of the MET gene, N375S (rs33917957 A>G), may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis. In this study, we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls. Logistic regression analysis was applied to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and gastric cancer risk. We found that MET N375S variant genotypes (NS/SS) were associated with a significantly decreased risk of gastric cancer (OR = 0.78, 95% CI = 0.63-0.96, P = 0.021) compared with the wildtype homozygote (NN). The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.
Highlights
The incidence of gastric cancer decreased in the past decades, gastric cancer remains the fourth most common cancer and the second leading cause of cancer related death worldwide
It is of great importance to identify genetic variations that are associated with gastric cancer risk and potentially useful in gastric cancer risk prediction
We found that a germline variation in MET, N375S, was associated with a significantly decreased gastric cancer risk
Summary
The incidence of gastric cancer decreased in the past decades, gastric cancer remains the fourth most common cancer and the second leading cause of cancer related death worldwide. About half of global gastric cancer cases occur in China, and the incidence. *Corresponding author: Hongbing Shen, Ph.D, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, China. Mortality rates (per 100,000 persons) were 42.4 and 28.1 for men and 18.3 and 13.0 for women, respectively.[1] Helicobacter pylori (H. pylori) infection has been established as a risk factor in stomach carcinogenesis[2]. Genetic factors may play a critical role in the development of gastric cancer[3].
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