Abstract
Anthropological studies based on the highly polymorphic gene, human leukocyte antigen (HLA), provide useful information for bone marrow donor registry, forensic medicine, disease association studies, as well as infertility treatment, designing peptide vaccines against tumors, and infectious or autoimmune diseases. The aim of this study was to determine HLA-A and HLA-B allele frequencies in 100 unrelated Lak/lᴂk/individuals from Lorestan province of Iran. Finally, we compared the results with that previously described in Iranian population. Commercial HLA-Type kits from BAG (Lich, Germany) company were used for determination of the HLA-A and HLA-B allele frequencies in genomic DNA, based on polymerase chain reaction with sequence specific primer (PCR-SSP) assay. The differences between the populations in distribution of HLA-A and HLA-B alleles were estimated by chi-squared test with Yate's correction. The most frequent HLA-A alleles were *24 (20%), *02 (18%), *03 (12%) and *11 (10%), and the most frequent HLA-B alleles were *35 (24%), *51 (16%), *18 (6%) and *38 (6%) in Lak population. HLA-A*66 (1%), *74(1%) and HLA-B*48 (1%), *55(1%) were the least observed frequencies in Lak population. Our results based on HLA-A and HLA-B allele frequencies showed that Lak population possesses the previously reported general features of Iranians but still with unique.
Highlights
Among the basic medical sciences involving in anthropology, immunology can be considered as a science which deals with the molecular markers playing role in recognition of self and non-self between ethnicities [1]
The human leukocyte antigen (HLA) called as major histocompatibility complex (MHC) [6] with the length of 3600 kb is located on chromosome 6 and includes 239 antigenic loci that about 40% of them are immunogenic [7]
The main role of HLA class I is that this biological molecule acts as an identifying card for all nuclear cells of body to be proposed for natural killer cells (CD56CD16 [14]) that different interactions between them results in different outcomes [15]
Summary
Among the basic medical sciences involving in anthropology, immunology can be considered as a science which deals with the molecular markers playing role in recognition of self and non-self between ethnicities [1]. Biomedicine is not alien to anthropology and offers an ethnographic international classification of ethnicities based on the immunological molecules such as CD markers [2,3]. N2000 alleles for HLA class I are known in humans [8]. The main role of HLA class I is that this biological molecule acts as an identifying card for all nuclear cells of body to be proposed for natural killer cells (CD56CD16 [14]) that different interactions between them results in different outcomes [15]. In addition to the key roles considered by immunologists for HLA, such genes have attracted the view point of most developmental biologists because of a high level of allele variety
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
