A Genome-Wide Scan on Individual Typology Angle Found Variants at SLC24A2 Associated with Skin Color Variation in Chinese Populations

Abstract

Skin pigmentation functions as a shield to prevent UV damage to the DNA of epidermal cells. A good number of GWASs on skin color variation or skin photosensitivity have been conducted that discovered a large number of associated loci (Ganguly et al., 2019). Polymorphisms/mutations at these loci have been used to study the molecular type of skin color for individuals from different continental groups (Chen et al., 2021) and have been associated with various forms of albinism (Marçon and Maia, 2019), loss of photoprotection, and increased rates of photoaging (Liu et al., 2016).