Abstract

Purpose: Cartilage is vital for joint health and function with its degeneration being a key feature of osteoarthritis (OA). Minimum joint space width measured on X-rays (mJSWX-ray) or high-resolution dual-energy X-ray absorptiometry images (mJSWDXA) can provide a proxy for cartilage thickness and pathological joint space narrowing (JSN). Defining the genetic architecture of mJSW provides a route to identify new biological pathways involved in JSN pathogenesis, some of which may represent future therapeutic targets.

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