A GENOME WIDE ASSOCIATION STUDY OF DXA-DERIVED MINIMUM JOINT SPACE WIDTH OF THE HIP PROVIDES FURTHER INSIGHTS INTO ITS GENETIC ARCHITECTURE: FINDINGS FROM UK BIOBANK

B Faber,M Frysz,R Ebsim,M Lundberg,L Southam,A Hartley,F.R Saunders,C Lindner,J.S Gregory,R.M Aspden,N.C Harvey,E Zeggini,G Davey Smith,T Cootes,J.P Kemp,J.H Tobias

doi:10.1016/j.joca.2022.02.051

A GENOME WIDE ASSOCIATION STUDY OF DXA-DERIVED MINIMUM JOINT SPACE WIDTH OF THE HIP PROVIDES FURTHER INSIGHTS INTO ITS GENETIC ARCHITECTURE: FINDINGS FROM UK BIOBANK

B Faber, M Frysz + Show 14 more

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https://doi.org/10.1016/j.joca.2022.02.051

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Journal: Osteoarthritis and cartilage	Publication Date: Mar 28, 2022
License type: publisher-specific-oa

Affiliation: University of Bristol, University of Manchester, University of Queensland, Helmholtz Zentrum München, University of Aberdeen, University of Southampton

#Joint Space Narrowing #Joint Space + Show 8 more

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Abstract

Purpose: Cartilage is vital for joint health and function with its degeneration being a key feature of osteoarthritis (OA). Minimum joint space width measured on X-rays (mJSWX-ray) or high-resolution dual-energy X-ray absorptiometry images (mJSWDXA) can provide a proxy for cartilage thickness and pathological joint space narrowing (JSN). Defining the genetic architecture of mJSW provides a route to identify new biological pathways involved in JSN pathogenesis, some of which may represent future therapeutic targets.

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