Abstract
Objective:To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS).Methods:We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed.Results:We found no significant loci after stringent multiple testing correction. A number of regions emerged as potentially interesting for follow-up at p < 1 × 10−6, including SNPs in the genes FBXO47, ELOVL7, EDN1, and MAPT. Contrary to previous reports, we found no association of the genes SNCA and COQ2 with MSA.Conclusions:We present a GWAS in MSA. We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation in SNCA and COQ2 does not seem to be associated with MSA. In the future, additional samples of well-characterized patients with MSA will need to be collected to perform a larger MSA GWAS, but this initial study forms the basis for these next steps.
Highlights
Under the log-additive model, power analysis for this study indicated greater than 80% power to detect associated loci with an odds ratio greater than 1.8 at risk allele frequencies between 7% and 87%
Samples were successfully genotyped for 267,998 single nucleotide polymorphisms (SNPs) and imputed to 4,903,804 SNPs
We identified 4 loci for future follow-up in a larger sample series at a p value,1 3 1027 including the genes FBXO47, ELOVL7, endothelin-1 gene (EDN1), and MAPT
Summary
We performed a GWAS with .5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed. MD, PhDGallWy AmSatwchitehdpactoienntrtoslws.itCh oMlleScAtioonf Esuitreospefoanr ancestry and regionthis study included. Thomas Gasser, MD brain banks and clinical centers in Germany, Austria, Netherlands, Gregor K. MD, Denmark, the United Kingdom, Italy, Portugal, Spain, and the United States (table e-1 at Neurology.org). PhD recruited in different geographic regions across Europe and the
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