Abstract
Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (Screening Set 11) were genotyped. Quantitative linkage analyses were performed using family regression and variance components methods. We found linkage on the 7q36 region [D7S3058, 174 centimorgan (cM), Logarithm of Odds (LOD) = 2.98] for log-transformed TG. We also found suggestive linkages on chromosomes 20 (D20S164, 101 cM, LOD = 2.34), 13 (111 cM, LOD = 2.00), and 9 (104 cM, LOD = 1.90) as well as some weaker trends for chromosomes 1, 3, 5, 10, 12, and 22. In 58 African American families, LOD scores of 3.66 and 2.62 were observed on two loci on chromosome 16: D16S3369 (64 cM) and MFD466 (100 cM). To verify the 7q36 linkage, we added 60 nuclear families, and the LOD score increased to 3.52 (empirical P < 0.002) on marker D7S3058.
Highlights
Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance
Mutations of the ABC1 gene cause Tangier disease, an autosomal recessive disease characterized by hypertriglyceridemia, hypocholesterolemia, and absence of normal HDL in plasma [Mendelian Inheritance in Man (MIM) 205400] [21]
Linkages on chromosome region 7qtel for plasma TG Based on our genome scan data (382 microsatellite markers and 320 families: 260 European American and 58 African American), we carried out quantitative linkage analyses for serum TG
Summary
Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. Genome scan results for body weight-related phenotypes (BMI, percentage fat, and waist circumferences) in 260 European American families were reported elsewhere [26]. Log-transformed, adjusted serum TG levels were analyzed using the family regression test [multipoint linkage using MERLIN_regress [29]].
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